Inhibition of α-Glucosidase Activity and Islet Amyloid PolyPeptide Fibril Formation by <i>Rubus</i><i>ulmifolius</i> Fruit Extract: A Potential Therapeutic Approach for Type 2 Diabetes Mellitus.

ABSTRACT: This study examines the antidiabetic potential of Rubus ulmifolius, a shrub traditionally used for medicinal and nutritional purposes. The aim was to assess the fruit extract's inhibitory effect on α-amylase and α-glucosidase, therapeutic targets in type 2 diabetes (T2D), given their role in carbohydrate digestion. Considering the role of islet amyloid polypeptide (IAPP) aggregation in pancreatic β-cell dysfunction in T2D, the extract's effect on inhibiting this process was also evaluated. Cytocompatibility and antioxidant effects were tested in Caco-2 cells, while caspase-1 activity was measured to evaluate anti-inflammatory potential. Phytochemical analysis of R. ulmifolius fruits revealed various phenolic compounds, with anthocyanin as the most abundant one. The cyanidin-3

SUBMITTER: Floris S 

PROVIDER: S-EPMC12608329 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature