Potential Antiviral Compounds from <i>Hippeastrum puniceum</i> Bulb Against Yellow Fever Virus: Bioassay-Guided Fractionation and <i>In Silico</i> Pharmacokinetic Analysis.

ABSTRACT: Despite the availability of effective vaccines, yellow fever outbreaks persist, highlighting the need for antiviral drugs.

Background/objectives

This study investigated Hippeastrum puniceum (Amaryllidaceae) as a potential source of antiviral compounds against wild-type yellow fever virus (wt-YFV).

Methods/results

The crude bulb extract of H. puniceum exhibited 58% protection against wt-YFV. Bioassay-guided fractionation of the extract by UHPLC-HRMS led to the annotation of six alkaloids (bulbisine, cathinone, trigonelline, tetrahydroharman-3-carboxylic acid, and 2,7-dimethoxyhomolycorine or 3-O-acetylnarcissidine) in active fractions, along with the amino acids arginine, asparagine, tryptophan, and glutamic acid. In silico ADMET analyses predicted favorab

SUBMITTER: Flores-Souza E 

PROVIDER: S-EPMC12608337 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature