Pentosidine and Bone Properties in Autosomal Dominant Polycystic Kidney Disease.

ABSTRACT: Background/Objectives: Altered bone metabolism and oxidative stress are features of autosomal dominant polycystic kidney disease (ADPKD). Pentosidine, an advanced glycation end-product and a marker of oxidative stress, has been proposed as an indicator of impaired bone health. This study aimed to evaluate whether pentosidine levels are altered in ADPKD and whether they are associated with bone characteristics in comparison with other chronic kidney disease (CKD) etiologies and healthy individuals. Methods: We conducted a cross-sectional analysis of three cohorts comprising 554 adults. Participants were categorized by CKD etiology and stage (G1-G5). ADPKD stages were classified according to the Mayo Imaging Classification (MIC). Plasma pentosidine was analyzed by HPLC and ELIS

SUBMITTER: Jankowska M 

PROVIDER: S-EPMC12608610 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature