Perineural and Lymphovascular Invasion in Resected Pancreatic Ductal Adenocarcinoma: A High-Risk Subgroup That Could Benefit from Adjuvant Radiotherapy.

ABSTRACT: Background: Perineural invasion (PNI) and lymphovascular invasion (LVI) are adverse prognostic factors in pancreatic ductal adenocarcinoma (PDAC). Their concurrence may warrant intensified adjuvant therapy. This study investigated the prognostic impact of concurrent PNI and LVI and the potential benefit of adjuvant radiotherapy. Methods: A retrospective analysis was conducted in patients who underwent pancreaticoduodenectomy for PDAC (2015-2023). Patients were grouped as PNI only, concurrent PNI and LVI, or neither. Clinicopathological features and survival outcomes were compared. In the concurrent PNI and LVI subgroup, the effect of adjuvant radiotherapy was analyzed according to margin status (R0 vs. R1). Disease-free survival (DFS) and overall survival (OS) were assessed u

SUBMITTER: Gumus T 

PROVIDER: S-EPMC12608663 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature