PLGA Nanoparticles Double-Decorated with a TAT Peptide and Folic Acid to Target <i>Staphylococcus aureus</i>.

ABSTRACT: Treating bacterial infections has become increasingly difficult due to the rise in antibiotic-resistant bacterial strains. Strategies involving the targeted delivery of antibiotics have been proposed to minimize the administered antibiotic doses. This study aims to develop the first double-modified nanovehicle capable of increasing bacterial membranes' permeability while specifically targeting Staphylococcus aureus, one of the foremost pathogens responsible for global mortality rates. Thus, polymeric NPs composed of poly(lactic-co-glycolic acid) (PLGA) were produced, and their surface was modified with TAT peptide to increase the membranes' permeability and folic acid (FA) to direct the NPs to S. aureus. The nanosystem showed spherical morphology with sizes of 174 ± 4 nm, a m

SUBMITTER: Andrade S 

PROVIDER: S-EPMC12608785 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature