Diagnosis of Secondary Bacterial Meningitis via Aromatic Metabolites and Biomarkers in Cerebrospinal Fluid.

ABSTRACT: The development of sensitive and specific diagnostic methods for secondary bacterial meningitis remains an urgent challenge in neurosurgical and intensive care units. A combination of various clinical and biochemical parameters, as well as biomarkers and metabolites in cerebrospinal fluid (CSF), can be considered for constructing multivariate diagnostic models. In this study, 96 CSF samples from 53 patients with suspected secondary meningitis were analyzed. The first cohort, consisting of patients with sequelae of severe brain damage, included 7 patients (21 CSF samples) with and 29 patients (56 CSF samples) without secondary bacterial meningitis. The second cohort comprised patients after neurosurgical interventions, including 10 patients (12 CSF samples) with and 7 patients (7 CSF sample

SUBMITTER: Meinarovich PA 

PROVIDER: S-EPMC12609026 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature