A Comparative Study of <i>C</i><sub>2</sub>-Symmetric and <i>C</i><sub>1</sub>-Symmetric Hydroxamic Acids in Vanadium-Catalyzed Asymmetric Epoxidation of Allylic Alcohols.
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ABSTRACT: Hydroxamic acids are emerging as versatile chiral ligands for metal-catalyzed asymmetric oxidations due to their tunable electronic and steric environments. In this study, we systematically compared the catalytic behavior of C2- and C1-symmetric hydroxamic acid ligands in the vanadium-catalyzed asymmetric epoxidation of allylic alcohols. A series of chiral hydroxamic acids (HA1-HA7) was synthesized and evaluated under varied conditions to elucidate the influence of ligand symmetry on enantioinduction and reactivity. The results demonstrate that C2-symmetric bishydroxamic acids generate a highly organized chiral environment, leading to high enantioselectivity but often limited conversion, consistent with the Sabatier principle. Conversel
SUBMITTER: Valtierra-Galvan M
PROVIDER: S-EPMC12609139 | biostudies-literature | 2025 Nov
REPOSITORIES: biostudies-literature
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