Impact of Isoquinoline Alkaloids on the Intestinal Barrier in a Colonic Model of <i>Campylobacter jejuni</i> Infection.

ABSTRACT: Phytotherapy is a growing field of modern medicine, offering natural alternatives with multidirectional pharmacological effects. Among plant-derived bioactive compounds, isoquinoline alkaloids exhibit antioxidant, anti-inflammatory, and antimicrobial properties. Our in vitro model of campylobacteriosis confirmed that berberine reduces pathological changes in colonocytes not only through its direct antibacterial (minimum inhibitory concentration for pure berberine against Campylobacter jejuni was 64 μg/mL) and anti-biofilm (fourfold reduction in C. jejuni biomass) effects, but also through its protective effect on the morphostructure and secretory profile of host cells exposed to bacterial components. Furthermore, berberine stabilized intercellular junction proteins, modulated

SUBMITTER: Duda-Madej A 

PROVIDER: S-EPMC12609152 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature