Neuroprotection by Flaxseed Oil in a Model of Hippocampal Injury Induced by Trimethyltin Involves Purinergic System Modulation.

ABSTRACT: A large body of evidence suggests that flaxseed oil (FSO), one of the richest sources of essential omega-3 fatty acids, has neuroprotective properties. Purinergic signaling plays a crucial role in pathophysiological processes in the nervous system. There is a lack of evidence regarding the effects of FSO on the purinergic system under both physiological and neurotoxic conditions. Here we report the effects of dietary FSO consumption in a rat model of trimethyltin (TMT) intoxication. Exposure to TMT selectively induces hippocampal neuronal damage and glial reactivation associated with oxidative stress and neuroinflammation, causing severe behavioral impairments. When administered orally (1 mL/kg) before and during TMT intoxication (single dose 8 mg/kg, i.p.) to female Wistar rats, FSO effec

SUBMITTER: Mitrovic N 

PROVIDER: S-EPMC12609297 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature