Molecular Implications of <i>ADIPOQ, GAS5, GATA4</i>, and <i>YAP1</i> Methylation in Triple-Negative Breast Cancer Prognosis.

ABSTRACT: The aim of this study was to investigate the prognostic and predictive properties of four specific genes in triple-negative breast cancer (TNBC). We focused on ADIPOQ, GAS5, GATA4, and YAP1, which are known for their roles in key molecular pathways related to tumorigenesis, such as adipokine signaling, lncRNA regulation, transcriptional control, and Hippo signaling, but have not been sufficiently explored in the context of epigenetic regulation in breast cancer. Using the methylospecific PCR (MSP) method, we analyzed the methylation of the four genes in the tumor tissues collected from 57 TNBC patients. We evaluated their association with response to neoadjuvant treatment and clinicopathological characteristics. Additionally, we performed a bioinformatic analysis of methylati

SUBMITTER: Wichtowski M 

PROVIDER: S-EPMC12609348 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature