Red Blood Cell Fatty Acid Patterns and Cognitive Functions in Adolescents: A Pooled Analyses with Two Cohort Study Data Sets.

ABSTRACT: Objective: Fatty acids (FAs) play a pivotal role in brain development and cognitive functions during adolescence. We aimed to investigate the association of red blood cell (RBC) FA patterns and several high order neuropsychological functions in adolescents. Methods: The study followed a cross-sectional design. Principal component analysis was applied to 22 FA species previously measured in RBC membranes (exposure variable) to identify FA principal components (PCs) from two cohorts of adolescents in Catalonia, Spain (mean age = 14.53 years). Multiple linear regression was then used to examine associations between PC FAs and cognitive outcomes-working memory, fluid intelligence, and risky decision-making (gain and loss domains). Regression models were adjusted for child sex, ag

SUBMITTER: Ayala-Aldana N 

PROVIDER: S-EPMC12609364 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature