Chitosan Nanoformulations of Mycosporine-like Amino Acid (MAA)-Rich Extracts from <i>Mazzaella laminarioides</i> Effectively Protect Human Keratinocytes Against UVA Radiation Damage.

ABSTRACT: Mycosporine-like amino acids (MAAs) are secondary metabolites of interest for the development of natural sunscreens, owing to their antioxidant activity and ultraviolet radiation (UVR)-absorbing properties. MAA-rich aqueous extracts obtained from the Chilean red alga Mazzaella laminarioides (locally known as luga cuchara) were analyzed by HPLC and loaded into chitosan nanoparticles (CSNPs), with an encapsulation efficiency of 90.1%. The resulting CS nanoformulations (CSNFs) were characterized by FTIR spectroscopy, DLS and TEM microscopy, confirming the presence of nanoparticles with a core diameter of 94 ± 11 nm and FTIR absorption bands accounting for CS functional groups. Pre-treatment of HaCaT keratinocytes with CSNFs conferred complete protection against low-to-moderate UVA dose

SUBMITTER: Vasquez O 

PROVIDER: S-EPMC12609401 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature