<i>Lactiplantibacillus plantarum</i>, Duodenal Hydroxyphenyllactic Acid and Iron: Insights from a Rat Model of a High-Fat Iron-Deficient Diet.

ABSTRACT: Background: Lactiplantibacillus plantarum synthesizes in vitro hydroxyphenyllactic acid (HPLA)-an iron-reducing agent supposed to facilitate duodenal Fe absorption. So far, no such in vivo HPLA production has been established. This study aimed to investigate the ability of Lactiplantibacillus plantarum to produce HPLA in the duodenum in rats on a high-fat iron-deficient diet. Methods: Rats were fed a high fat (HF) diet; HF, Fe-deficient diet (HFDEF); or control (C) diet for 8 weeks. Over the next 8 weeks, animals in the C and HF groups continued on their respective diets, while animals in the HFDEF group were divided into six subgroups and received combinations of an HF, Fe-deficient diet with Lactiplantibacillus plantarum (Lp), Latilactobacillus curva

SUBMITTER: Skrypnik K 

PROVIDER: S-EPMC12609434 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature