A Proanthocyanidins-Rich Cili (<i>Rosa roxburghii</i>) Fruit Extract Protects CCl₄-Induced Mouse Hepatic Fibrosis via Modulation of Ferroptosis and Gut Microbiota.

ABSTRACT: Background: Cili (Rosa roxburghii Tratt) is a unique fruit native to China's Yunnan-Guizhou Plateau, rich in vitamin C, polyphenols, and triterpene, with broad health-promoting effects. Although cili's hepatoprotective properties are reported, the bioactive components and underlying mechanisms remain poorly defined. Methods: We enriched proanthocyanidins from cili using column chromatography, identified their components via UPLC-Q-TOF-MS/MS, and validated their anti-liver fibrosis effects through in vitro and in vivo experiments. Results: Herein, we developed a novel proanthocyanidin-rich cili fruit extract (PACs-CFE) containing 84.2% total proanthocyanidins, comprising catechins, epicatechins, and diverse B-type dimers, trimers, tetramers, and gallate esters, a

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12609504 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature