Amorphous Lycopene-PVP K30 Dispersions Prepared by Ball Milling: Improved Solubility and Antioxidant Activity.

ABSTRACT: Lycopene is a carotenoid with strong antioxidant properties, but its therapeutic potential is limited by its poor aqueous solubility. Developing formulations that enhance its solubility and stability may improve its bioavailability and effectiveness. This study aimed to prepare amorphous lycopene-PVP K30 systems via ball milling, a solvent-free and mild technique, and to evaluate their physicochemical properties, solubility, and antioxidant activity. Formulations containing 5%, 10%, and 15% lycopene (w/w) were obtained and characterized using X-ray powder diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy. Density Functional Theory calculations were performed to gain molecular-level insights into lycopene-polymer interactions and hydro

SUBMITTER: Kulawik A 

PROVIDER: S-EPMC12609523 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature