Immunotherapy Plus Surgery Improves Survival in Microsatellite Instability-High Colon Cancer with Isolated Peritoneal Metastases.

ABSTRACT:

Background

Microsatellite instability-high (MSI-H) colon cancer with isolated peritoneal metastases (iPM) represents a molecularly and anatomically distinct clinical subset with limited evidence to guide treatment. Given the unique immunogenic profile of MSI-H tumors and the historically poor prognosis of peritoneal dissemination, we evaluated the association of immunotherapy, chemotherapy, and surgery with survival outcomes in this population.

Methods

Using the National Cancer Database, we identified patients with MSI-H colon cancer and iPM diagnosed between 2016-2021. Patients were stratified by systemic therapy type (immunotherapy, chemotherapy, combination) and surgical resection status. Kaplan-Meier and multivariable Cox regression analyses were used to assess overall s

SUBMITTER: Metzger DA 

PROVIDER: S-EPMC12609588 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature