Advancing Prostate Cancer Assessment: A Biparametric MRI (T2WI and DWI/ADC)-Based Radiomic Approach to Predict Tumor-Stroma Ratio.

ABSTRACT: Objectives: This study aimed to develop and validate a biparametric MRI (bpMRI)-based radiomics model for the noninvasive prediction of tumor-stroma ratio (TSR) in prostate cancer (PCa). Additionally, we sought to explore lesion distribution patterns in the peripheral zone (PZ) and transition zone (TZ) to provide deeper insights into the biological behavior of PCa. Methods: This multicenter retrospective study included 223 pathologically confirmed PCa patients, with 146 for training and 39 for internal validation at Center 1, and 38 for external testing at Center 2. All patients underwent preoperative bpMRI (T2WI, DWI acquired with a b-value of 1400 s/mm², and ADC maps), with TSR histopathologically quantified. Regions of interest (ROIs) were manually segmented on

SUBMITTER: Ma J 

PROVIDER: S-EPMC12609615 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature