Cell-Free DNA Hypermethylation in Patients with Acute Pancreatitis.

ABSTRACT: Cell-free DNA (cfDNA) promoter hypermethylation shows promise as a blood-based biomarker for pancreatic cancer, and similar alterations may occur in acute pancreatitis (AP). This study investigated the cfDNA hypermethylation profile of AP patients over time, compared with healthy controls, and its association with AP severity markers. A prospective longitudinal study including hospitalized AP patients and healthy controls was conducted. Methylation-specific PCR of a 23-gene panel was performed on plasma collected at inclusion (T0), 6 weeks (T6W), 6 months (T6M), and 7-8 years (T8Y). Associations between gene hypermethylation and clinical markers of AP severity-CRP, leukocyte count, creatinine, hospital stay, and complications-were evaluated. AP patients had a significantly higher mean numb

SUBMITTER: Al-Mashat H 

PROVIDER: S-EPMC12609792 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature