Comparative Analysis of Two Autophagy-Enhancing Small Molecules (AUTEN-67 and -99) in a <i>Drosophila</i> Model of Spinocerebellar Ataxia Type 1.

ABSTRACT: Autophagy is a lysosome-mediated self-degradation process of eukaryotic cells which is critical for the elimination of cellular damage. Its capacity progressively declines with age, and this change can lead to the development of various neurodegenerative pathologies including Spinocerebellar ataxia type 1 (SCA1). SCA1 is mainly caused by mutations in the polyglutamine region of Ataxin 1 protein. In patients affected by the disease, Purkinje neurons of the cerebellum frequently undergo demise and eventually become lost. Here we tested whether two well-characterized autophagy-enhancing small molecules, AUTEN-67 and -99, which antagonize the autophagy complex Vps34 through blocking the myotubularin-related lipid phosphatase MTMR14/EDTP, have the capacity to ameliorate SCA1 symptoms. We found

SUBMITTER: Burjan T 

PROVIDER: S-EPMC12609819 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature