Conformational Analysis of 3-Indoleacetamide: Unveiling Structural Rigidity in the Tryptophan-Derived Bioactive Molecule Family.

ABSTRACT: The conformational landscape of 3-indoleacetamide, a key intermediate in plant hormone biosynthesis, has been comprehensively investigated using state-of-the-art laser-ablation chirped-pulse Fourier transform microwave (LA-CP-FTMW) and laser-ablation molecular beam Fourier transform microwave (LA-MB-FTMW) spectroscopy. Remarkably, 3-indoleacetamide exhibits unprecedented conformational rigidity within the tryptophan-derived molecule family, displaying only a single stable conformer characterized by distinctive a-, b-, and c-type rotational transitions. This singular conformational behavior contrasts dramatically with the structural flexibility observed in closely related tryptophan derivatives such as tryptophan, serotonin, tryptamine, and 3-indoleacetic acid. The uniq

SUBMITTER: Municio S 

PROVIDER: S-EPMC12609830 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature