Kv7 Channels as an Important Contributor to Alcohol-Induced Modulation of Neuronal Excitability in Neonatal Rat Superior Cervical Ganglion.

ABSTRACT: Normal alcohols (n-alcohols) exhibit contrasting effects on neuronal excitability; specifically, ethanol enhances neuronal firing, while hexanol suppresses it. Both compounds are known to inhibit sodium currents, yet the mechanisms behind their differing effects remain unclear. Our previous studies demonstrated that Kv7 channels are modulated differently by alcohol chain length, prompting investigation into their role in these contrasting effects. We conducted whole-cell patch clamp recordings on neonatal (P5-P7) rat superior cervical ganglion neurons to assess alcohol impacts on action potential firing and ionic currents, utilizing tetrodotoxin (TTX), XE991, and retigabine (RTG). Ethanol (100 mM) increased action potential frequency, whereas hexanol (3 mM) decreased it, despite bot

SUBMITTER: Jeong DJ 

PROVIDER: S-EPMC12609967 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature