The Proteomic Landscape of <i>CTNNB1</i> Mutated Low-Grade Early-Stage Endometrial Carcinomas.

ABSTRACT: Endometrial carcinoma is the most frequent gynecologic malignancy in western countries. In recent years, mutations in CTNNB1 have been associated with worse prognosis in low-risk carcinomas. However, there is a lack of understanding of the proteomic implications of CTNNB1 mutations in this type of tumor. In this study, we performed shotgun proteomics using Formalin-Fixed Paraffin-Embedded (FFPE) tissue samples of CTNNB1 mutated and wild-type low-risk endometrial carcinomas. A publicly available proteomic and transcriptomic database was used to validate results. Differential protein expression and Gene Set Enrichment Analysis revealed dysregulation of pathways associated with cell keratinization, immune response modulation, and intracellular calcium regulation. CTNNB

SUBMITTER: Lopez-Janeiro A 

PROVIDER: S-EPMC12610012 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature