Fit Hearts, Better Outcomes? A Systematic Review and Meta-Analysis of Exercise Intensity and Peak VO₂ in Hypertrophic Cardiomyopathy.

ABSTRACT: Background: This study aimed to systematically review and analyze the available evidence on the safety and efficacy of physical activity (PA) in patients with HCM. Methods: We conducted a systematic search of PubMed, Cochrane, and Web of Science databases up to March 30, 2025. Fourteen studies (4 RCTs) were included in the qualitative synthesis and ten in the quantitative synthesis, totaling 10478 patients. Results: The meta-analysis demonstrated a significant improvement in peak VO₂ in the moderate intensity PA (MIPA) group, with a mean difference of 1.77 mL/kg/min (95% CI: 0.93 to 2.60, I² = 38.2%, p = 0.19), while changes in body mass index were not significant (MD: -0.66 kg/m²; 95% CI: -1.77 to 0.44; I² = 62%; p

SUBMITTER: Djuranovic A 

PROVIDER: S-EPMC12610065 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature