Diagnostic Performance of Serum Neutrophil-Lymphocyte and Serum Monocyte-Lymphocyte Ratios in Periprosthetic Joint Infection: A Comparative Meta-Analytic Review of 29 Studies.

ABSTRACT: Background/Objectives: Periprosthetic joint infection (PJI) remains one of the most devastating complications of arthroplasty, with early diagnosis crucial for successful management. The serum neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR) have been proposed as simple, inexpensive inflammatory biomarkers, but their diagnostic performance in PJI remains unclear. This meta-analysis aimed to compare the diagnostic accuracy of serum NLR and MLR in detecting PJI. Materials and Methods: A systematic literature search was conducted in PubMed, Web of Science, and Scopus up to April 2025. Twenty-nine eligible studies (n = 14,040 patients; 3418 with PJI, 10,622 without PJI) reporting diagnostic metrics for serum NLR or MLR were included. Extracted data com

SUBMITTER: Birlutiu RM 

PROVIDER: S-EPMC12610077 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature