An examination of the quinic acid utilization genes in Aspergillus niger reveals the involvement of 2 pH-dependent permeases.

ABSTRACT: Many microorganisms are able to use plant-derived aromatic and cyclic compounds like the common plant secondary metabolite quinic acid as carbon and energy sources. In fungi, 3 enzymatic steps convert quinic acid into the common intermediate protocatechuic acid, which is then further converted into tricarboxylic acid cycle intermediates. The genes encoding these 3 enzymes are known to be part of a gene cluster in Neurospora crassa along with a permease, a gene of unknown function, and an activator-repressor module controlling expression of the cluster. This gene cluster is conserved in fungi and has also been studied in Aspergillus nidulans, where an additional gene of unknown function is included. Here, we studied these genes in the filamentous fungus Aspergillus niger, where the availabi

SUBMITTER: Sgro M 

PROVIDER: S-EPMC12610400 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature