Metabolic Disruption in Osteoporotic Sheep: Evaluating Vitamin D Deficiency and Cortisone Effects via Biochemical Markers.

ABSTRACT:

Background/objectives

We evaluated serum and urinary biomarkers of bone and energy metabolism in an ovine osteoporosis model (Control, OVX, OVXD, OVXDS) at 0/3/8 months (M).

Methods

Morning sampling; DXA (ROI 'abdominal width') and linear mixed models for repeated measures.

Results

Only OVXDS showed severe DXA loss (Z-scores -3.29 at 3 M; -4.86 at 8 M), with ≈20% and ≈30% BMD reductions at 3 M and 8 M versus controls. OVX and OVXD remained within age-expected Z-score ranges at 8 M. At 3 M, OVXDS had hypocalcemia, markedly elevated UFEP, near-zero 25-OH-vitamin-D, and suppressed osteocalcin/NTX (depressed turnover). By 8 M, osteocalcin rose in OVXDS while NTX stayed low, consistent with altered coupling under chronic glucocorticoids and vitamin D deficiency. OVXD showe

SUBMITTER: Knapp G 

PROVIDER: S-EPMC12610466 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature