Cobalt-Catalyzed C-Se Bond Activation: Cross-Coupling of Organoselenides with Grignard Reagents.

ABSTRACT: Herein, we report a cobalt-catalyzed cross-coupling of organoselenides with Grignard reagents using simple CoCl₂ as the catalyst. This efficient method accommodates a broad scope of selenides, including vinyl, aryl, heteroaryl, and alkynyl derivatives, under mild and ligand-free conditions. Remarkably, the reaction proceeds efficiently without additives and afforded the desired products in moderate to good yields within just 3 h.

SUBMITTER: de Souza Pinto TV 

PROVIDER: S-EPMC12610506 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature