Safety Assessment and Probiotic Potential of a Novel Species <i>Lactobacillus xujianguonis</i>.

ABSTRACT: Background: Some lactobacilli strains have been documented to cause bacteremia and sepsis in immunocompromised or critically ill hospitalized patients, challenging the universally presumed safety of lactobacilli. Therefore, strain-specific risk assessments are required for the use of Lactobacillus as a probiotic. Lactobacillus xujianguonis, a novel Lactobacillus species isolated from Marmota himalayana, has probiotic potential but lacks safety data. Objective: To evaluate the preclinical safety of L. xujianguonis for food-grade use. Methods: Systematic safety assessment includes in vitro studies and oral toxicity studies. In vitro studies encompassed gastrointestinal tolerance, auto-aggregation and pathogen inhibition, a

SUBMITTER: Lin X 

PROVIDER: S-EPMC12610698 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature