Characterizing the Clinical and Molecular Profile of SETD2-Mutated Lung Adenocarcinoma.

ABSTRACT: Introduction: SETD2 is an understudied gene that encodes for a histone methyltransferase implicated in lung cancer tumorigenesis and is found in up to 10% of all non-small cell lung cancer. With the largest cohort to date, we aim to elucidate the clinicopathologic characteristics and prognosis of SETD2-mutated lung adenocarcinoma. Methods: We obtained molecular genetics reports of lung cancer seen between 1 January 2015 and 4 January 2024. We identified all SETD2-mutated cancer and identified 500 consecutive cases prior to 4 January 2020 as a control group. Non-recurrent adenocarcinomas were included. Patient and tumor characteristics and recurrence-free survival (RFS) were compared. Fisher's exact, Wilcoxon rank sum, and log-rank tests were used when app

SUBMITTER: Bushara O 

PROVIDER: S-EPMC12610740 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature