An International Inter-Consortium Validation of Knowledge-Based Plan Prediction Modeling for Whole Breast Radiotherapy Treatment.

ABSTRACT:

Background

Knowledge-based (KB) planning is a promising approach to model prior planning experience and optimize radiotherapy. To enable the sharing of models across institutions, their transferability must be evaluated. This study aimed to validate KB prediction models developed by a national consortium using data from another multi-institutional consortium in a different country.

Methods

Ten right whole breast tangential field (RWB-TF) models were built within the national consortium. A cohort of 20 patients from the external consortium was used for testing. Transferability was defined when the ipsilateral (IPSI) lung first principal component (PC1) was within the 10th-90th percentile of the training set. Predicted dose-volume parameters were compared with clinical dose-vo

SUBMITTER: Placidi L 

PROVIDER: S-EPMC12610825 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature