Lipoxin A4 Regulates M2 Macrophage-Derived Exosomal miR-25-5p to Protect Cell Pyroptosis in Bronchopulmonary Dysplasia.

ABSTRACT: Bronchopulmonary dysplasia (BPD) involves macrophage-driven immunoinflammation, while macrophage-derived exosomes act as key extracellular vehicles linking macrophage-driven inflammation with tissue injury. Emerging evidence suggests that Lipoxin A4 (LXA4) modulates macrophage immune responses. However, the precise role of LXA4 in regulating macrophage function in BPD and its underlying mechanisms remains unclear. Neonatal rats were exposed to 85% hyperoxia to establish a BPD model. LXA4 or M2-polarized macrophage-derived exosomes (M2-exo) were injected intraperitoneally, and pulmonary inflammation, macrophage polarization and pyroptosis were examined. M2-exo were co-cultured with type II alveolar epithelial cells (AT2) to further validate the animal experimental findings and explore under

SUBMITTER: Chen T 

PROVIDER: S-EPMC12611187 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature