Kynurenine Pathway Dysregulation Impairs Podocyte Morphology and Bioenergetics In Vitro and Leads to Glomerular Dysfunction.

ABSTRACT: Managing tryptophan (TRP) availability is important for cell homeostasis, and a dynamic balance between dietary intake and its catabolism is crucial. The enzymes of the kynurenine pathway (KP) mediate the main catabolic route for TRP. Its intermediary products, collectively known as kynurenines, are considered metabolically active and highly pleiotropic. Some progress has been made in the description of the biological function of the kynurenines, and despite the growing number of studies that show an association between TRP metabolism and kidney function, not much is known about the cellular mechanisms involved. To assess if the kynurenines play a role in glomerular dysfunction, we carried out a series of experiments aimed at describing the effect of changes in the relative abundance of th

SUBMITTER: Bolanos-Palmieri P 

PROVIDER: S-EPMC12611232 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature