Calcium starvation leads to strain-specific gene regulation of lipid and carotenoid production in Mucor circinelloides.

ABSTRACT: Fungi are pivotal in transitioning to a bio-based, circular economy due to their ability to transform organic material into valuable products such as organic acids, enzymes, and drugs. Mucor circinelloides is a model organism for studying lipogenesis and is particularly promising for its metabolic capabilities in producing oils like TAGs and carotenoids, influenced by environmental factors such as nutrient availability. Notably, strains VI04473 and FRR5020 have been identified for their potential in producing single-cell oils and carotenoids, respectively. Calcium starvation has previously been shown to have strain-specific effects, with VI04473 accumulating more lipids and FRR5020 producing more carotenoids. Here, we used genome sequencing, comparative genomics, transcriptomics, and metab

SUBMITTER: Baalsrud HT 

PROVIDER: S-EPMC12611239 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature