Integrated ecdysone and O-linked N-acetylglucosamine signaling coordinates intestinal stem cell proliferation in Drosophila midgut.

ABSTRACT: Steroid hormones and nutrient-sensitive signaling pathways play critical roles in the regulation of stem cell activity, maintenance of tissue homeostasis, and the coordination of metabolic functions. In Drosophila, the steroid hormone ecdysone and the nutrient-responsive posttranslational modification O-linked N-acetylglucosaminylation (O-GlcNAcylation) are emerging as key regulators of intestinal stem cell (ISC) behavior. This study aimed to investigate how the interplay between ecdysone signaling and O-GlcNAcylation controls ISC proliferation and gut homeostasis, particularly in the context of aging. We showed that ecdysone receptor (EcR) expression increases during aging and upon increased O-GlcNAcylation and that both genetic overexpression of EcR and exogenous 20-hydroxyecdysone treat

SUBMITTER: Na HJ 

PROVIDER: S-EPMC12611247 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature