Rearrangement of 3D genome organization in breast cancer epithelial to mesenchymal transition and metastasis organotropism.

ABSTRACT: Human breast cancer cells exhibit organotropism during metastasis, showing preferential homing to certain organs such as bone, lung, liver, and brain. Spatial genome organization plays a crucial role in oncogenic transformation and progression, but the extent to which chromosome architecture contributes to organ-specific metastatic traits is unclear. This work characterizes chromosome architecture changes associated with organotropic metastatic traits. By comparing a collection of human genomic data from different subtypes of localized and lung metastatic breast cancer cells with both normal and cancerous lung cells, we find important trends of genomic reorganization. The most striking differences in 3D genome compartments segregate cell types according to their epithelial vs. mesenchymal

SUBMITTER: Das P 

PROVIDER: S-EPMC12611262 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature