Calcium transfer from the ER to other organelles for optimal signaling in <i>Toxoplasma gondii</i>.

ABSTRACT: Ca²⁺ signaling in cells begins with the opening of Ca²⁺ channels in either the plasma membrane (PM) or endoplasmic reticulum (ER), leading to a sharp increase in the physiologically low (<100 nM) cytosolic Ca²⁺ level. The temporal and spatial regulation of Ca²⁺ is crucial for the precise activation of key biological processes. In the apicomplexan parasite Toxoplasma gondii, which infects approximately one-third of the global population, Ca²⁺ signaling governs essential aspects of the parasite's infection cycle. T. gondii relies on Ca²⁺ signals to regulate pathogenic traits, with several Ca²⁺-signaling components playing critical roles. Ca²⁺ entry from the extracellular environment has been

SUBMITTER: Li ZH 

PROVIDER: S-EPMC12611264 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature