First Direct Evidence of Accelerated Molecular Aging in Intracranial Aneurysmal Tissue.

ABSTRACT: The risk for cardiovascular diseases increases with age. Various markers for vascular aging have been suggested. However, these markers are not a direct measure of aging in vessels. Telomere length quantification can directly measure vascular aging-the current study aimed to investigate aging in aneurysm tissue by quantifying telomere length. Non-diseased control vessels and ruptured and unruptured intracranial aneurysm vessels were resected during surgery. Telomere length quantification revealed a shorter telomere length in intracranial aneurysm tissue than in the non-diseased control vessel. The difference in telomere length between non-diseased control vessels and intracranial aneurysm tissue remained significant after normalizing for age. Moreover, the intracranial aneurysm tissue show

SUBMITTER: Khan D 

PROVIDER: S-EPMC12611279 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature