Lactate Secretion by Monocytes as a Determinant of Innate Immune Cell Fitness in Healthy Elderly.

ABSTRACT: Immune cell metabolism is increasingly recognized as an important regulator of immune function, but its role in age-related immune dysfunction, chronic inflammation, and cardiometabolic complications in humans remains incompletely understood. This study investigated the impact of aging on monocyte metabolic and functional signatures in a healthy elderly population. We aimed to leverage these immunometabolic signatures to identify healthy elderly individuals with reduced immune cell fitness and, therefore, potentially at a higher risk for age-related complications. We characterized lactate and cytokine secretion, phagocytic capacity, and glycolytic and oxidative metabolic responses in monocytes from 103 elderly individuals and included 52 young adults as a reference group with healthy immun

SUBMITTER: Smeehuijzen L 

PROVIDER: S-EPMC12611318 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature