Protein Catabolites as Blood-Based Biomarkers of Aging Physiology: Findings From the Dog Aging Project.

ABSTRACT: Our understanding of aging has grown through the study of systems biology, including single-cell analysis, proteomics and metabolomics. Studies in lab organisms in controlled environments, while powerful and complex, fall short of capturing the breadth of genetic and environmental variation in nature. Thus, there is now a major effort in geroscience to identify aging biomarkers that might be applied across the diversity of humans and other free-living species. To meet this challenge, the Dog Aging Project (DAP) aims to identify cross-sectional and longitudinal patterns of aging in complex systems, and how these are shaped by the diversity of genetic and environmental variation among companion dogs. Here we surveyed the plasma metabolome from the first year of sampling of the Precision Coho

SUBMITTER: Harrison BR 

PROVIDER: S-EPMC12611326 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature