Prognostic Significance of Actinin-4 Protein Expression and Gene Amplification in Endometrial Carcinoma.

ABSTRACT:

Objective

This study aimed to investigate the clinical significance of actinin-4 in endometrial carcinoma. Actinin-4, an actin-binding protein involved in cytoskeletal dynamics, has been implicated in the progression of various cancers; however, its precise role in endometrial carcinoma is not fully understood. This research sought to evaluate actinin-4 protein expression and gene amplification and correlate these findings with clinicopathological parameters and patient survival to determine its prognostic value.

Methods

A retrospective analysis was conducted on endometrial carcinoma patients who underwent surgical resection. Actinin-4 protein expression was assessed using immunohistochemical staining (IHC), and ACTN4 gene amplification was evaluated by fluorescence in situ

SUBMITTER: Xiang L 

PROVIDER: S-EPMC12611447 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature