Effects of adjunctive dobutamine on outcomes among patients with septic shock: a propensity score matching analysis.

ABSTRACT:

Background/aims

Despite some evidence supporting its utility, the role of adjunctive dobutamine in the management of septic shock remains unclear.

Methods

The nationwide prospective sepsis cohort of the Korean Sepsis Alliance was analyzed. Adult patients with septic shock receiving norepinephrine were enrolled over a 29-month period. Patients given a dobutamine infusion within 3 days of intensive care unit (ICU) admission were compared with patients who received no infusion. To balance baseline characteristics, propensity score matching (PSM) was used.

Results

Of 11,981 patients with sepsis, 1,827 patients with septic shock receiving norepinephrine were included (108 dobutamine vs. 1,719 no dobutamine; mean age 71.4 ± 13.2 years, 59.4% male). After PSM (ratio of 1:2;

SUBMITTER: Lim SY 

PROVIDER: S-EPMC12611483 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature