Exosomal miRNA-720 as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma.

ABSTRACT:

Background/aims

Circulating exosomal microRNAs (miRNAs) can serve as diagnostic and prognostic biomarkers for cancer. This study aimed to identify specific miRNAs in serum exosomes of patients with hepatocellular carcinoma (HCC) and validate their biological functions as novel diagnostic and predictive biomarkers.

Methods

Serum exosomal miRNAs in patients with HCC (n = 241) and without HCC (n = 45) were measured by qRT-PCR. The role of exosomal miRNAs in HCC was investigated through in vitro tests and verified in a clinical cohort of patients.

Results

In vitro, we observed delivery of exosomal miRNA-720 (miR-720) to recipient cells. Exosome-mediated miR-720 promoted proliferation and inhibited apoptosis of recipient HCC cells. Exosomal miR-720 inhibited tumor suppress

SUBMITTER: Kim JM 

PROVIDER: S-EPMC12611490 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature