Cardiac structure and function and quality of life associations in HFpEF: An analysis from TOPCAT-Americas.

ABSTRACT:

Background

Patients with heart failure with preserved ejection fraction (HFpEF) have poor health-related quality of life (HR-QoL). However, the relationship between HR-QoL measures and the alterations of cardiac structure and function that are present in patients with HFpEF remains unknown.

Aims

To study the associations between HR-QoL and echocardiographic parameters in HFpEF.

Methods

Regression modelling in patients from TOPCAT-Americas who had both HR-QoL questionnaires and a baseline echocardiogram.

Results

A total of 631 patients (36% of the TOPCAT-Americas population) had both echocardiographic and HR-QoL at baseline. KCCQ-23 Overall Summary Score (OSS; 0-100 points) was negatively (higher echocardiographic values-poorer/lower HR-QoL scores) associated wi

SUBMITTER: Ferreira JP 

PROVIDER: S-EPMC12611552 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature