Left atrial structure and function of the amyloidogenic V122I transthyretin variant in elderly African Americans.

ABSTRACT:

Aims

African-American carriers of the transthyretin (TTR) valine-to-isoleucine substitution (V122I) are at increased risk of heart failure, yet many have relatively subtle abnormalities of left ventricular (LV) function. We sought to explore the influence of this mutation on left atrial (LA) structure and function in this population.

Methods and results

We assessed 1225 genotyped African-Americans (age range, 67-89 years) participating in the Atherosclerosis Risk in Communities study who underwent echocardiography and were in sinus rhythm at study Visit 5 (2011 to 2013). Six LA parameters [LA maximum/minimum volume index, ejection fraction, and LA reservoir, conduit, and contractile longitudinal strains (LS)] were compared between V122I TTR variant carriers (n = 46) and non-

SUBMITTER: Minamisawa M 

PROVIDER: S-EPMC12611555 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature