Chromosomal clustering of a human transcriptome reveals regulatory background.

ABSTRACT:

Background

There has been much evidence recently for a link between transcriptional regulation and chromosomal gene order, but the relationship between genomic organization, regulation and gene function in higher eukaryotes remains to be precisely defined.

Results

Here, we present evidence for organization of a large proportion of a human transcriptome into gene clusters throughout the genome, which are partly regulated by the same transcription factors, share biological functions and are characterized by non-housekeeping genes. This analysis was based on the cardiac transcriptome identified by our genome-wide array analysis of 55 human heart samples. We found 37% of these genes to be arranged mainly in adjacent pairs or triplets. A significant number of pairs of adjacent ge

SUBMITTER: Vogel JH 

PROVIDER: S-EPMC1261156 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature