Drug-induced liver injury associated with selective androgen receptor modulators in an adolescent patient.

ABSTRACT: Selective androgenic receptor modulators (SARMs) have similar properties to anabolic steroids but bind to androgen receptors in a tissue-specific manner. Studies have investigated the benefits of SARMs in promoting bone and muscle growth while limiting the adverse effects of androgenic stimulation of other organs. However, an increase in the reported cases of hepatotoxicity in adults secondary to SARMs found in bodybuilding supplements has raised concerns about their safety. We report the first known adolescent case of SARMs-associated liver injury with a primarily hepatocellular pattern of injury. Previous reports in adults had shown a primarily cholestatic pattern of injury. Our case highlights, the variations in the phenotypic and histologic patterns of injury based on the amount and ty

SUBMITTER: Katibian DJ 

PROVIDER: S-EPMC12611585 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature