Impact of albuminuria on early-onset type 2 diabetes mellitus: a nationwide population-based study.

ABSTRACT:

Background

Early-onset diabetes mellitus has a significant lifetime burden and is associated with higher morbidity and mortality. Since insulin resistance is one of the mechanisms of podocyte injury, we aimed to evaluate the effect of albuminuria on newly developed early-onset type 2 diabetes mellitus (T2DM).

Methods

We screened 6,891,399 subjects aged ≥20 and <40 years without a history of prediabetes or diabetes from the Korean National Health Insurance Service database between 2009 and 2012. A multivariate Cox proportional hazard model was used to identify the impact of albuminuria on early-onset T2DM.

Results

Among a total of 5,383,779 subjects, 62,148 subjects (1.2%) developed early-onset diabetes over 7.3 ± 1.2 years. Albuminuria was significantly associated wit

SUBMITTER: Lee S 

PROVIDER: S-EPMC12611606 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature