Identification of Disulfidptosis-Associated Hub Genes in Psoriasis via Integrated Transcriptomic and Experimental Validation Approaches.

ABSTRACT: Psoriasis is a chronic, immune-mediated skin disease. While redox imbalance has been implicated in its pathogenesis, the involvement of newly identified cell death pathways remains unclear. Disulfidptosis, a novel form of regulated cell death driven by intracellular disulfide stress, has recently been linked to inflammatory and metabolic diseases, yet its role in psoriasis is unknown. We conducted an integrative analysis combining bulk transcriptomic data (GSE106992 and GSE11239) and single-cell RNA sequencing data (GSE162183) to identify disulfidptosis-related genes (DRGs) associated with psoriasis. Differentially expressed genes were intersected with a curated DRG list. Feature selection was performed using LASSO regression and random forest algorithms, followed by WGCNA to identify key

SUBMITTER: Liu S 

PROVIDER: S-EPMC12611608 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature