Innovative molecular targets for combatting metastasis in adrenocortical carcinoma.

ABSTRACT:

Background

Metastasis in adrenocortical carcinoma (ACC) presents a formidable clinical challenge, with limited insights into its underlying mechanisms and few effective treatment options. This study aimed to identify molecular markers associated with metastasis in adult ACC and to explore novel therapeutic approaches.

Methods

RNA sequencing data from 74 adult ACC patients were analyzed using bioinformatics approaches, including weighted gene co-expression network analysis (WGCNA) and differential gene expression analysis. Functional pathway enrichment analyses were conducted to identify metastasis-associated genes and to explore key biological pathways contributing to metastatic progression. Candidate genes were selected based on their statistical significance, prognostic re

SUBMITTER: Kong J 

PROVIDER: S-EPMC12611695 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature