Spatiotemporal dynamics of the cardioimmune niche during lesion repair.

ABSTRACT: The heart is one of the least regenerative organs in humans, and ischemic heart disease is the leading cause of death worldwide. Understanding the cellular and molecular processes that occur during cardiac wound healing is an essential prerequisite to reducing health burden and improving cardiac function after myocardial tissue damage. Here, by integrating single-cell RNA sequencing with high-resolution spatial transcriptomics, we reconstruct the spatiotemporal dynamics of the fibrotic niches after cardiac injury in adult mice. We reveal a complex multicellular network that regulates cardiac repair, including fibroblast proliferation silencing by Trem2^high macrophages to prevent excessive fibrosis. We further discovered a rare population of progenitor-like cardiomyocytes after l

SUBMITTER: Chan AS 

PROVIDER: S-EPMC12611762 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature